DICLOFENAC SODIUM USE

DICLOFENAC USE

Continuing Education ActivityDiclofenac is a medication used in the management and treatment of inflammatory conditions and pain. It is in the class of non-steroidal anti-inflammatory drugs (NSAID). This activity outlines the indications, mechanism of action, administration, adverse effect profile, contraindications, and other key factors for diclofenac in the clinical setting pertinent to healthcare team members to treat and manage patients with inflammation-related conditions. Objectives: Outline the mechanisms of action of diclofenac.Review the indications for therapy with diclofenac.Summarize the potential adverse reactions of diclofenac. Outline the importance of improving care coordination among the interprofessional team to improve outcomes for patients receiving diclofenac. Access free multiple choice questions on this topic.



Voltaren and Voltarol contain the sodium salt of diclofenac. In the United Kingdom, Voltarol can be supplied with either the sodium salt or the potassium salt, while Cataflam, sold in some other countries, is the potassium salt only. However, Voltarol Emulgel contains diclofenac diethylammonium, in which a 1.16% concentration is equivalent to a 1% concentration of the sodium salt. In 2016 Voltarol was one of the biggest selling branded over-the-counter medications sold in Great Britain, with sales of £39.3 million.[52]

Kidney problems can sometimes occur with the use of NSAID medications, including diclofenac. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have pink/bloody urine or any unusual change in the amount of urine.



Important considerations for using diclofenacKeep these considerations in mind if your doctor prescribes diclofenac for you.RefillsA prescription for this medication is refillable. You shouldn’t need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.TravelWhen traveling with your medication:Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.Don’t worry about airport X-ray machines. They can’t harm your medication.You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.Clinical monitoringIf you use diclofenac for a long time, your doctor should do blood tests to check your kidney and liver function at least once a year.You should check your own blood pressure from time to time. Home blood pressure monitors are available at most pharmacies and online.Shop online for blood pressure monitors.Sun sensitivityYou may have increased sensitivity to the sun while using diclofenac. To protect your skin, use sunscreen with SPF 30 or greater.AvailabilityNot every pharmacy stocks this drug. However, you may be able to order it. When filling your prescription, be sure to call the pharmacy first to make sure they stock this drug or can order it for you.Prior authorizationMany insurance companies require a prior authorization for this form of this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.If your insurance company won’t cover this form, you may consider checking whether it will cover the tablet or capsule form instead.



Diclofenac initiators had a 50% increased rate of major adverse cardiovascular events compared with NSAID non-initiators (incidence rate ratio 1.5, 95% confidence interval 1.4 to 1.7). Supporting use of a combined endpoint, event rates consistently increased for all individual outcomes: 1.2-fold for atrial fibrillation or flutter, 1.6-fold for ischaemic stroke, 1.7-fold for heart failure, 1.9-fold for myocardial infarction, and 1.7-fold for cardiac death (fig 2 and eTable 5). Cardiac death was driven by death from heart failure (incidence rate ratio 2.3, 1.3 to 4.2), cardiac arrhythmia (1.9, 1.1 to 3.3), and myocardial infarction (1.7, 1.2 to 2.4).

Diclofenac can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Different brands of diclofenac contain different amounts of this medicine, and may have different uses. If you switch brands, your dose needs may change. Follow your doctor's instructions about how much medicine to take. Ask your pharmacist if you have any questions about the brand of diclofenac you receive at the pharmacy.Swallow the whole and do not crush, chew, or break it. tablet Take on an empty stomach, at least 1 hour before or 2 hours after a meal. ZorvolexCall your doctor if your headache does not completely go away after taking Cambia.Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.Follow all directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Use the lowest dose that is effective in treating your condition.Dissolve diclofenac powder with 1 to 2 ounces of water. Do not use any other type of liquid. Stir this mixture and drink all of it right away. Diclofenac powder works best if you take it on an empty stomach. (Cambia)If you use diclofenac long-term, you may need frequent medical tests.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen, ketorolac, naproxen). These drugs are similar to diclofenac and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

What will happen if I stop taking it? When you stop taking diclofenac tablets or capsules, or stop using the suppositories, the effects will wear off after about 15 hours.When you stop using the gel, plasters or patches, the effects will wear off after 1 or 2 days.

ContraindicationsLike other selective COX-2 inhibitors, diclofenac is contraindicated with an FDA boxed warning in patients with a history of increased cardiovascular risk such as MI or stroke. Diclofenac should not be used in bypass graft surgery of coronary artery due to a higher risk of MI and stroke. Diclofenac is also listed as a Beers list drug and should be avoided in elderly patients due to potential adverse effects involving the cardiovascular and gastrointestinal systems. It is also contraindicated in patients with a history of anaphylactoid reaction to NSAID drugs.Also, diclofenac is contraindicated in patients with mild or severe renal insufficiency due to potential negative effects of decreased renal perfusion. Clinicians should not use diclofenac or other NSAIDs in patients with a history of GI bleeds or ulcerations. Special monitoring is a consideration in patients with a history of Helicobacter pylori infection. Formulations of diclofenac with misoprostol are contraindicated in pregnant females due to possible side effects involving loss of pregnancy associated with misoprostol.

Diclofenac is a medication used in the management and treatment of inflammatory conditions and pain. It is in the class of non-steroidal anti-inflammatory drugs (NSAID). This activity outlines the indications, mechanism of action, administration, adverse effect profile, contraindications, and other key factors for diclofenac in the clinical setting pertinent to healthcare team members to treat and manage patients with inflammation-related conditions.

Patient Counseling Information This drug may cause dizziness, drowsiness or blurred vision, if affected, do not drive or operate machinery. Avoid excessive exposure of affected area to sunlight (transdermal or topical/cutaneous). Remove contact lenses prior to administration and reinsert after 15 minutes (ophthalmic).

Diclofenac Sodium 50mg with food and drinkTake this medicine with or after food.Pregnancy and breast-feeding Although not common, abnormalities have been reported in babies whose mothers have taken NSAIDs during pregnancy. You should not take DICLOFENAC SODIUM 50mg tablets during the last 3 months of pregnancy as it may affect the baby's circulation.You should advise your doctor or pharmacist if you think you might be pregnant or are up to 6 months pregnant.Taking Diclofenac Sodium 50mg tablets may make it more difficult to become pregnant. You should talk to your doctor if you are planning to become pregnant, or if you have problems getting pregnant.You should avoid taking Diclofenac Sodium whilst breast feeding.

Depending on why you're taking diclofenac, you may only need to take it for a short time. For example, if you have a sore back or toothache, you may only need to take diclofenac for 1 or 2 days.

Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain, and gastrointestinal bleeding.Label Hypertension, acute renal failure, respiratory depression and coma occur rarely. In case of overdose, provide supportive care and consider inducing emesis and administering activated charcoal if overdose occurred less than 4 hours prior.

See also Warning section.The enteric-coated tablet form of diclofenac is used to reduce pain, swelling (inflammation), and joint stiffness from arthritis. Reducing these symptoms helps you do more of your normal daily activities.Diclofenac is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.Ask your doctor about non-drug treatments and/or using other medications to treat your pain.

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CLOBITA GM CREAM

Clobita gm

Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.

In wet places such as changing rooms and gym showers, don't walk on barefoot. Wear flip-flops or sandals to prevent fungal infections.Do not scratch the affected area of skin as it can spread the infection to other body parts.Avoid sharing towels, combs, bedsheets, shoes or socks with others to prevent the spread of infection.Wash your bed sheets and towels regularly.Eat foods rich in quercetin, such as apples, 

cherry, broccoli, spinach and blueberries.Consuming food rich in probiotics helps in developing the immune system against allergies.Limit foods like dairy products, soy, eggs, and nuts that might trigger allergies.Avoid the consumption of foods with excess sugar as it may flare up inflammation.Include fruits, vegetables, whole grains, healthy fats and fish in your diet.Avoid getting in contact with harsh soaps, detergents and rough fabrics.



Clobeta GM Cream 10 gm is a combination of Borax, Clobetasol, Miconazole, and Neomycin. Clobetasol is a corticosteroid that inhibits the release of certain chemical messengers in the body that cause redness,

 itching and swelling. Miconazole is an antifungal that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is an antibiotic that inhibits the production of essential proteins that are necessary for bacteria to grow,

 multiply and increase in numbers. Borax is an additive mineral that provides necessary nutrients, removes dead skin cells and prevents microbial infections. Thereby, together it kills the microbes and keeps your skin free from microbial infections.



The festive season is around the corner and we are gearing up to celebrate with our near and dear ones. Along with celebrations, most festive periods come with unhealthy binge eating, leading to fitness regimes going for a toss and several health issues settling in. So the million-dollar question is; How do you eat healthy

A: No, it should not be used for burns. You should not apply this cream on the skin surface which has cuts, wounds or burns.



Diet & Lifestyle AdviseRegularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.In wet places such as changing rooms and gym showers, don't walk on barefoot. Wear flip-flops or sandals to prevent fungal infections.Do not scratch the affected area of skin as it can spread the infection to other body parts

.Avoid sharing towels, combs, bedsheets, shoes or socks with others to prevent the spread of infection.Wash your bed sheets and towels regularly.Eat foods rich in quercetin, such as apples, cherry, broccoli, spinach and blueberries.Consuming food rich in probiotics helps in developing the immune system against allergies.

Limit foods like dairy products, soy, eggs, and nuts that might trigger allergies.Avoid the consumption of foods with excess sugar as it may flare up inflammation.Include fruits, vegetables, whole grains, healthy fats and fish in your diet.Avoid getting in contact with harsh soaps, detergents and rough fabrics.

Medicinal BenefitsClobeta GM Cream 10 gm is a combination of Borax, Clobetasol, Miconazole, and Neomycin. Clobetasol is a corticosteroid that inhibits the release of certain chemical messengers in the body that cause redness, itching and swelling. Miconazole is an antifungal that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is an antibiotic that inhibits the production of essential proteins that are necessary for bacteria to grow, multiply and increase in numbers. Borax is an additive mineral that provides necessary nutrients, removes dead skin cells and prevents microbial infections.

 Thereby, together it kills the microbes and keeps your skin free from microbial infections.

Clobeta GM Cream 10 gm is a combination of Clobetasol (corticosteroid), Miconazole (antifungal), Neomycin (antibiotic), and Borax (an additive that removes dead skin and microbes). Clobetasol blocks the production of prostaglandins (chemical messengers), making the skin red, swollen and itchy. Miconazole is an antifungal agent that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is an antibiotic used in treating bacterial and fungal infections of the skin. 

It prevents the synthesis of essential proteins required by bacteria to carry out vital functions. Borax is a mineral that provides necessary nutrients to the body.

I am using this clobeta gm for ring worm at this .where it seems to be like curing, the red colour has being healing. Dr.Jyoti Biswas MBBS,MD(medicine) General Physician, Kolkata Clobetasol alone is not enough. You need 2 oral medicine and 2 creams for 1 month .then it will be curable need details evaluation and treatment you can chat with me clicking on" text consultation" option if you wish thanks.

A: Both Clobeta GM and Lobate GM are topical antimicrobial and steroid medicines that are used for the treatment of various skin conditions. However, they differ in their composition. Clobeta GM cream contains a combination of clobetasol, zinc, borax, neomycin, and miconazole as the active substances while Lobate GM cream contains clobetasol, neomycin, 

and miconazole as active substances. You should always use the medicine that is prescribed to you by your doctor.

Clobeta GM Cream 10 gm belongs to a class of dermatological medication that is used to reduce swelling, itching and redness caused due to bacterial and fungal skin infections. Fungal infection is a skin disease in which a fungus attacks the tissue and causes an infection. Bacterial skin infection occurs when bacteria penetrate through hair follicles or the skin breaks and infects the skin.Clobeta GM Cream 10 gm is a combination of Clobetasol (corticosteroid), Miconazole (antifungal), Neomycin (antibiotic), and Borax (an additive that removes dead skin and microbes). Clobetasol blocks the production of prostaglandins (chemical messengers), making the skin red, swollen and itchy. Miconazole is an antifungal agent that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is an antibiotic used in treating bacterial and fungal infections of the skin. It prevents the synthesis of essential proteins required by bacteria to carry out vital functions. Borax is a mineral that provides necessary nutrients to the body.Clobeta GM Cream 10 gm is for external use only. 

It is generally safe to use. Some may experience side effects like dry skin, burning, irritation, itching, and redness at the application site. Most of these side effects of Clobeta GM Cream 10 gm do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.Brief your medical history to the doctor, if you are allergic to Clobeta GM Cream 10 gm or any of its components. Let your doctor know if have any fungal infections or any viral infections, 

acne, rosacea, and psoriasis. Pregnant and breastfeeding women should use Clobeta GM Cream 10 gm with proper consultation and caution. Do not wrap or cover the treated area with bandages unless advised by your doctor. Do not apply Clobeta GM Cream 10 gm to broken skin or cuts

. In case of accidental swallowing, contact a nearby poison control centre or consult a doctor immediately. If you have adrenal gland or liver problems, inform your doctor before taking Clobeta GM Cream 10 gm.

I am suffering from ringworm from 15 days, and I have used lobate gm cream and terbinaforce plus also but no result now am using clobeta gm cream, clobeta gm treat ringworm? Which cream I have to use for finish ringworm? Clobeta gm treat ringworm? Dr.Rejath Raj MD - Dermatology, Bachelor of Medicine, Bachelor of Surgery (M.B.B.S.), Medicine Dermatologist, Bangalore Good afternoon. Clobate gm worsens ringworm. Kindly consult a qualified dermatologist either in person or via online consultation for proper treatment of your condition. Avoid self medicating for your own good.

A: Burning, irritation, itching, thinning of skin are a few common side effects that can be observed during the treatment with this cream. However, these symptoms are usually mild and resolve on your own. Also, it is not important that everyone experience the same.

The festive season is around the corner and we are gearing up to celebrate with our near and dear ones. Along with celebrations, most festive periods come with unhealthy binge eating, leading to fitness regimes going for a toss and several health issues settling in. So the million-dollar question is; How do you eat healthy Read More

Avoid These Foods If You Have Anxiety Or Depression!This article has been medically reviewed by Dr Nikita Toshi. Isn’t it a common practice to have something special for dinner or lunch when you have a reason to celebrate? Similarly, it is not unusual for many people to skip a meal or overeat when feeling low or angry. When we are feeling down or happy, Read More

About Clobeta GM Cream 10 gmClobeta GM Cream 10 gm belongs to a class of dermatological medication that is used to reduce swelling, itching and redness caused due to bacterial and fungal skin infections. Fungal infection is a skin disease in which a fungus attacks the tissue and causes an infection. Bacterial skin infection occurs when bacteria penetrate through hair follicles or the skin breaks and infects the skin.

Clobeta GM Cream 10 gm is a combination of Clobetasol (corticosteroid), Miconazole (antifungal), Neomycin (antibiotic), and Borax (an additive that removes dead skin and microbes). Clobetasol blocks the production of prostaglandins (chemical messengers), making the skin red, swollen and itchy. Miconazole is an antifungal agent that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is an antibiotic used in treating bacterial and fungal infections of the skin. It prevents the synthesis of essential proteins required by bacteria to carry out vital functions. Borax is a mineral that provides necessary nutrients to the body.Clobeta GM Cream 10 gm is for external use only. It is generally safe to use. Some may experience side effects like dry skin, 

burning, irritation, itching, and redness at the application site. Most of these side effects of Clobeta GM Cream 10 gm do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.Brief your medical history to the doctor, if you are allergic to Clobeta GM Cream 10 gm or any of its components. 

Let your doctor know if have any fungal infections or any viral infections, acne, rosacea, and psoriasis. Pregnant and breastfeeding women should use Clobeta GM Cream 10 gm with proper consultation and caution. 

Do not wrap or cover the treated area with bandages unless advised by your doctor. Do not apply Clobeta GM Cream 10 gm to broken skin or cuts. In case of accidental swallowing, contact a nearby poison control centre or consult a doctor immediately.

 If you have adrenal gland or liver problems, inform your doctor before taking Clobeta GM Cream 10 gm.

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SURFAZ AN CREAM USE

SURFAZ SN CREAM

Disease/Condition GlossaryThe swelling of the skin occurs when an allergic reaction or skin irritation releases several substances in the skin that widens blood vessels and cause itching, redness, pain, and swelling in the irritated area. Psoriasis is a skin condition in which skin cells multiply faster than normal, resulting in white scales and itchy, dry patches. Dermatitis is a common skin condition associated with dry, itchy, or swollen skin. Eczema is a skin condition that causes itchy, cracked, swollen, or rough skin.



Surfaz SN Cream 10 gm belongs to a class of topical corticosteroid medications used to treat skin conditions such as psoriasis, eczema and dermatitis. Surfaz SN Cream 10 gm contains Beclomethasone dipropionate, a corticosteroid having anti-inflammatory properties. It reduces swelling, redness, and itching by inhibiting the production of certain chemical messengers in the body that cause inflammation. Thus, Surfaz SN Cream 10 gm aids in treating skin conditions such as Psoriasis, Eczema and Dermatitis.



Are there any missed dose instructions? Contact your doctor for instructions if you missed a scheduled dose of this medication. A self-attempt to make up for the lost dose may result in adverse effects. Are there any overdose instructions? Contact your doctor if an overdose with this medication for is suspected especially when the prescribed dose is very high. Symptoms may include thinning of the skin, easy bruising and bleeding, body fat deposits etc.



Ans: Major and minor side effects of Surfaz-Sn Cream are itching, allergic contact dermatitis, acneiform eruptions, erythema, edema, and burning. Apart from these, it may also lead to conditions such as irritation, dryness, folliculitis, hypertrichosis, hypopigmentation, perioral dermatitis, maceration of the skin, secondary infections. These are rarely observed and the patient should contact a doctor immediately if any of these symptoms are experienced on a regular basis. These are reported in a small fraction of the population.

Surfaz SN Cream 10gm Information Surfaz SN Cream 10gm is a prescription medicine that is available as a Cream. Secondary and off-label uses of Surfaz SN Cream 10gm have also been mentioned below.The correct dosage of Surfaz SN Cream 10gm depends on the patient's age, gender, and medical history. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. Refer to the dosage section for a detailed discussion.Surfaz SN Cream 10gm also has some side effects, the most common being Skin Rash. While these are the most often observed Surfaz SN Cream 10gm side effects, there are can be others also. These have been listed below. These side effects of Surfaz SN Cream 10gm are usually temporary and subside with the completion of treatment. However, if these continue for a longer time, consult your doctor right away. Surfaz SN Cream 10gm's effect during pregnancy is Severe and Moderate while nursing. In addition, Surfaz SN Cream 10gm's effects on the liver, heart and kidney are discussed below in the Surfaz SN Cream 10gm related warnings section.Surfaz SN Cream 10gm can cause adverse effects in certain medical conditions. It is strongly recommended to avoid Surfaz SN Cream 10gm in conditions like Liver Disease, Scleroderma, Tuberculosis (TB). Some other conditions that can be affected by Surfaz SN Cream 10gm are listed in the contraindications section below.Additionally, Surfaz SN Cream 10gm may also adversely react with other medicines. See below for a complete list. In addition to the above precautions for Surfaz SN Cream 10gm, it is important to know that it is not safe while driving, and is not habit-forming.

Is it safe to use the cream in all stages of pregnancy? Although pregnant women have nothing to fear, if you are pregnant or you are planning to conceive, your doctor has to prescribe you the medication after learning about your condition. If he recommends, then the cream is safe for use.

Safety Precaution Use exactly as directed on the label, or as prescribed by your doctor. Inform your physician about all your medical conditions, any allergies, and any other topical medicines you use.

Safety AdviceAlcoholIt is not known if alcohol interacts with Surfaz SN Cream 10 gm. However, as a precautionary measure, limit or avoid the consumption of alcohol.PregnancySurfaz SN Cream 10 gm should only be used if your dermatologist or skin specialist has prescribed it and supervises your therapy.Breast FeedingPlease consult the doctor. It is given to nursing mothers only if the doctor thinks the benefits outweigh the risks. If you're using Surfaz SN Cream 10 gm on your breasts, wash off Surfaz SN Cream 10 gm from your breasts before feeding your baby.DrivingSurfaz SN Cream 10 gm does impact your ability to drive or operate machinery.LiverPlease consult your doctor if you have liver problems.KidneyPlease consult your doctor if you have kidney problems.

How many times should I apply the cream in a day? Ideally, applying a thin layer of the cream in the clean, affected area is recommended. However, your physician?s recommendation should be your holy grail.

This article has been medically reviewed by Dr Nikita Toshi. Isn’t it a common practice to have something special for dinner or lunch when you have a reason to celebrate? Similarly, it is not unusual for many people to skip a meal or overeat when feeling low or angry. When we are feeling down or happy,

A: Yes, Surfraz SN can be used for ringworm, a fungal infection. It contains clotrimazole which is effective in treating fungal infection. Surfraz SN ointment provides relief from various infections such as bacterial, fungal, or mixed. It kills and prevents the growth of the infection, thus providing relief from the symptoms of infection.

The festive season is around the corner and we are gearing up to celebrate with our near and dear ones. Along with celebrations, most festive periods come with unhealthy binge eating, leading to fitness regimes going for a toss and several health issues settling in. So the million-dollar question is; How do you eat healthy

About Surfaz-Sn Cream Surfaz-Sn Cream is primarily for the topical treatment of various dermal fungal infections. It is a combination of medicament containing Betamethasone, Clotrimazole, and Neomycin. It is helpful in treating many skin diseases including psoriasis and dermatitis and various others as well. This medicament also alleviates inflammatory symptoms including swelling, itching and redness. It is for external use only; do not use on open wounds. usually, it is applied twice daily, but you need to follow the doctors prescription for its dosage. Before applying, the patient must clean the skin and dry it. Also, he must wash and dry his hands before applying the medicament. You must rinse with water if its get into your eyes, mouth, nose or vagina. It may take a few days and even weeks for the symptoms of the disease to get improved. You must complete the course of treatment to ensure complete and better medicaments efficacy. One must inform their doctor if the condition does not improves or get worse. Before taking Surfaz-Sn Cream, you must inform your doctor if you are taking any other medicine for treating the same or any other disease, or pregnant/breastfeeding. The patient must refrain the use of this medicament if he/she is allergic to it and consult the doctor for alternative treatment for it. Also Read: Phlogam Tablet Uses and Side Effects

Betamethasone dipropionate is a highly potent corticosteroid prescription drug that can be used topically (applied to the skin) to treat inflammatory skin conditions. It should be used only under the supervision of a health care professional. Side effects from topical use include skin irritation and, with prolonged use, skin weakening or deterioration. Topical corticosteroids can be absorbed in sufficient amounts to produce adverse effects, including symptoms of adrenal suppression (low blood pressure, low blood sugar, weight loss, muscle pain, gastrointestinal problems, and severe fatigue) or Cushing’s syndrome (high blood pressure, high blood sugar, weight gain, muscle weakness, bone loss, and severe fatigue) depending on how much has been absorbed. Betamethasone dipropionate should not be used by pregnant or nursing women.

If I have kidney or liver ailments, can I use the cream? The surfaz sn cream has been rendered safe for those who suffer from kidney or liver ailments and there are no reports of any problems. However, do inform your doctor if your dosage shall be affected because of your ailments.

The correct dosage of Surfaz SN Cream 10gm depends on the patient's age, gender, and medical history. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. Refer to the dosage section for a detailed discussion.

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LOPERAMIDE TABLET USE

LOPERAMIDE TABLET USE

Loperamide should not be used when inhibition of peristalsis is to be avoided due to the possible risk of significant sequelae including ileus, megacolon and toxic megacolon. Loperamide must be discontinued promptly when constipation, abdominal distension or ileus develop.



Common questions about ImodiumHere are answers to some frequently asked questions about Imodium.What should I not take with Imodium?Because of possible drug interactions, you should avoid taking certain other medications with Imodium. However, there aren’t any foods, vitamins, herbs, or supplements known to interact with Imodium.Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.To see a list of drugs that may interact with Imodium, see the “Imodium interactions” section below.Can Imodium make you feel ‘high’?No, taking Imodium at the recommended dosage to treat diarrhea won’t make you feel “high.” At this dosage, Imodium doesn’t affect your brain. Instead, it only works inside your intestine.However, Imodium’s chemical structure is similar to that of opioids, such as morphine and heroin. If it’s misused and taken in extremely large doses, Imodium can affect your brain. And if it enters your brain, it may make you feel high.Some people misuse Imodium in this way to make themselves feel high. But you shouldn’t misuse Imodium, because doing so can have serious effects on your heart. (See the following question for more details).If you have questions about how Imodium may affect you, talk with your doctor or pharmacist.Is misusing Imodium dangerous?Yes, misusing Imodium can be very dangerous. (Misuse is also sometimes called abuse.)In fact, misusing Imodium can cause serious heart problems, such as an irregular heartbeat or heart attack. It can also cause loss of consciousness and slow, weak breathing. And it can sometimes even lead to death.Because of these risks, you should never take more Imodium than the dosage that’s recommended on the product labeling or by your doctor. If you have questions about the correct dosage for you, ask your doctor or pharmacist.What should I do if I’m still having diarrhea after taking Imodium?If you’re still having diarrhea after your first dose of Imodium, take another dose after each loose stool that follows. But only take doses up to the maximum daily dose. For more information about this, see the “Imodium dosage” section above.If you still have diarrhea after using Imodium for 2 days (48 hours), see your doctor. Your doctor may order certain tests to see what’s causing your diarrhea. And they may recommend a treatment other than Imodium, depending on the results of those tests.Will I be able to poop after I take Imodium?Yes, you should be able to. Imodium slows down the contractions in your intestine so that you pass firmer stools less often. But usually, the drug doesn’t completely stop you from having bowel movements.According to Imodium’s manufacturer, in clinical studies constipation occurred in less than 3% of people who took the drug. To read more about constipation with Imodium, see the “Imodium side effects” section below.If you’re concerned about not having bowel movements while you’re taking Imodium, talk with your doctor or pharmacist.Is Imodium safe to use?Yes, Imodium is generally considered to be a very safe drug when it’s taken correctly. (This means it’s taken according to the instructions on its product label or as instructed by your doctor.)To read about the possible side effects of Imodium, see the “Imodium side effects” section below.Is Imodium gluten free?It’s not known for sure. The manufacturer of Imodium hasn’t specified whether the drug is gluten free.Imodium is available in four different products:Imodium A-D oral solution, which is a liquidImodium A-D caplets, which are capsule-shaped tabletsImodium A-D softgels, which are liquid-filled capsulesImodium Multi-Symptom relief caplets, which are capsule-shaped tabletsGluten isn’t listed as an inactive ingredient for any forms of Imodium. (Inactive ingredients are ingredients in a medication that don’t affect how it works. Examples include ingredients added for coloring or flavoring.)However, it’s possible that Imodium is made in a facility that also makes products that contain gluten. In this case, the manufacturer can’t guarantee that Imodium products aren’t contaminated with gluten.If you have celiac disease or another condition that makes your body sensitive to gluten, talk with your doctor or pharmacist. They can advise if Imodium is safe for you to take. They may also recommend a gluten-free product for your condition

.If I have diarrhea from other drugs, such as metformin, can I take Imodium?Yes, it’s possible. If your doctor says it’s safe, you may be able to take Imodium for diarrhea that’s caused by other drugs. This includes metformin (Fortamet, Glumetza, Riomet), which is used to treat diabetes.However, before taking Imodium for this purpose, talk with your doctor. 

This is because, in certain situations, it’s not appropriate to self-treat diarrhea with Imodium.Your doctor may suggest different ways to treat diarrhea that’s caused by other drugs. For example, for metformin, it’s recommended that you take it with food to lessen diarrhea. Your doctor may also adjust your metformin dosage

.Before taking Imodium with other drugs, talk with your doctor or pharmacist. They can advise if it’s safe for you to take Imodium. Or they may suggest alternative treatments.



Because of possible drug interactions, you should avoid taking certain other medications with Imodium. However, there aren’t any foods, vitamins, herbs, or supplements known to interact with Imodium.



Frequently asked questions for LoperamideLoperamideQ. Is Loperamide safe?Loperamide is relatively safe if used as recommended. 

In case of any side effects, consult your doctor.Q. What is Loperamide used for?Loperamide is used for treating short-term or long-term diarrhea, with or without any associated disease.Q. Can Loperamide be used for IBS?Loperamide may be used in few cases of IBS but please consult your doctor before its use.Q. Can I take Loperamide with antibiotics, paracetamol, ibuprofen, omeprazole, ciprofloxacin, desmopressin, ritonavir, quinidine or cotrimoxazole?Loperamide may be taken simultaneously with antibiotics, paracetamol, ibuprofen, omiprazole or ciprofloxacin. Loperamide might interact with desmopressin, ritonavir, quinidine or cotrimoxazole. Please consult your doctor before useQ. Does Loperamide help in opiate withdrawal?Loperamide is used in higher doses as a part of opiate withdrawal process. However, do consult your doctor regarding the same.Q. Is Loperamide addictive?No, Loperamide is a safe and non-addictive anti-diarrheal drug.Q. Can Loperamide be used for stomach cramps, nausea, stomach flu, rota virus diarrhea and gas?Loperamide may benefit few cases of stomach cramps or nausea associated with diarrhea.

 It is sometimes used for stomach flu, rota virus diarrhea. It is not used for gas. Please consult your doctor before taking the drug.Q. Can I take Loperamide with cimetidine?Cimetidine can decrease the metabolism of Loperamide, increase its blood levels and hence, increase its effects and side effects. Your dose of Loperamide may needs to be decreased. Consult your doctor prior to taking both the drugs together.

The 13 included trials studied 1,788 children younger than 12 y: 975 children assigned to loperamide and 813 assigned to placebo. Of the 13 studies, six studies used loperamide doses ≤0.25 mg/kg/d, four studies used doses >0.25 mg/kg/d, and three studies used unclear maximum doses (Table 1).

Loperamide is approved to help control symptoms of diarrhea, including Travelers’ Diarrhea. The maximum approved daily dose for adults is 8 mg per day for OTC use and 16 mg per day for prescription use. It is sold under the OTC brand name Imodium A-D, as store brands, and as generics.

Non-clinical data have shown that loperamide is a P-glycoprotein substrate. Concomitant administration of loperamide (16 mg single dose) with quinidine, or ritonavir, which are both P-glycoprotein inhibitors, resulted in a 2 to 3-fold increase in loperamide plasma levels. The clinical relevance of this pharmacokinetic interaction with P-glycoprotein inhibitors, when loperamide is given at recommended dosages, is unknown. The concomitant administration of loperamide (4 mg single dose) and itraconazole, an inhibitor of CYP3A4 and P-glycoprotein, resulted in a 3 to 4-fold increase in loperamide plasma concentrations. In the same study a CYP2C8 inhibitor, 

gemfibrozil, increased loperamide by approximately 2-fold. The combination of itraconazole and gemfibrozil resulted in a 4-fold increase in peak plasma levels of loperamide and a 13-fold increase in total plasma exposure. These increases were not associated with central nervous system (CNS) effects as measured by psychomotor tests (i.e. subjective drowsiness and the Digit Symbol Substitution Test). The concomitant administration of loperamide (16 mg single dose) and ketoconazole, an inhibitor of CYP3A4 and P-glycoprotein, resulted in a 5-fold increase in loperamide plasma concentrations. 

This increase was not associated with increased pharmacodynamic effects as measured by pupillometry. Concomitant treatment with oral desmopressin resulted in a 3-fold increase of desmopressin plasma concentrations, presumably due to slower gastrointestinal motility. It is expected that drugs with similar pharmacological properties may potentiate loperamide's effect and that drugs that accelerate gastrointestinal transit may decrease its effect.

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GEMSOLINE-D3 CAPSULES USE

GEMSOLIN CAPSULE

If you are known to be allergic to Gemsoline Softgel Capsule 15's or its inactive components, please inform your doctor. Please tell your doctor if you have hypercalcemia (high calcium levels), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food). Brief your medical history if you have any heart/kidney/liver/blood vessel diseases, and kidney stones before starting Gemsoline Softgel Capsule 15's. Pregnant or breastfeeding women should consult their doctor before taking Gemsoline Softgel Capsule 15's. Higher doses of Vitamin D than the recommended daily dose should be used in pregnant women only when advised by the doctor. Gemsoline Softgel Capsule 15's may pass into the breast milk; hence breastfeeding mothers need to seek medical advice before starting Gemsoline Softgel Capsule 15's.



Use of gelling agents such as carrageenan and Gellan gum delays HPMC cell dissolution. Improved HPMC versions are available which do not require a secondary gelling agent (e.g., VCaps). HPMC dissolution and disintegration time is usually longer than that of hard gelatin capsules. 

Gelling agents may interact with cations in dissociating medium such as potassium and calcium ions. However, dissolution of improved newer versions of HPMC capsules is independent of pH and the ionic nature of dissociating medium.



What happens if I miss a dose?If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.



Gemsoline-D3 60K Soft Gelatin Capsule 4's works by blocking liver enzymes, causing the liver to make less cholesterol. So, Gemsoline-D3 60K Soft Gelatin Capsule 4's increases the uptake and breakdown by the liver of cholesterol already in the blood. Thus, Gemsoline-D3 60K Soft Gelatin Capsule 4's lowers the levels of lipids known as cholesterol and triglycerides in the blood when lifestyle changes (like a low-fat diet) on their own have failed. 

Gemsoline-D3 60K Soft Gelatin Capsule 4's reduces the ‘bad’ cholesterol and increases the ‘good’ cholesterol by blocking our body’s production of ‘bad’ cholesterol. It also improves your body’s ability to remove it from your blood. Cholecalciferol is added to relieve the muscle pain caused due to atorvastatin. Collectively, Gemsoline-D3 60K Soft Gelatin Capsule 4's helps reduce cholesterol levels in the blood.

Regarding the vegetarian versus nonvegetarian issue, defining vegetarian is a difficult issue, with special reference to variation among different religious beliefs present. Many a times, manufacturing of drugs requires different reagents of animal origin. Again, different drug products are also of nonvegetarian origin, for example, hormonal products, heparin, insulin, antiserum, and human cell line-derived products. Involvement of all these complicated issues makes determination of vegetarian and nonvegetarian capsules complicated. Again, this will create chaos between patients and doctors regarding the prescription of vegetarian versus nonvegetarian capsules. Scientific and manufacturing advantages can guide in this issue. On the ethical basis, representation says that gelatin-based capsules should be allowed to be marketed without any additional labeling. “Some members also pointed out that HPMC – a type of cellulose capsules – is basically of synthetic origin and as such cannot be considered as purely of vegetarian origin as in the case of food preparations,” the minutes noted. The DTAB's decision is in line with the 2013 Supreme Court decision which stated that cosmetics and drugs cannot be treated at par with food articles, when it comes to labeling them with a brown or a green mark to distinguish the vegetarian and nonvegetarian ingredients and hence, we are with the decision of the Supreme Court.

Capsule, a form of dosage form in medication, are common in our day-to-day health management. Capsules are made up of gelatin (hard or soft) and nongelatin shells generally derived from hydrolysis of collagen (acid, alkaline, enzymatic, or thermal hydrolysis) from animal origin or cellulose based. However, currently, an issue of vegetarian and nonvegetarian capsules is coming up. The Central Drugs Standard Control Organization (CDSCO) has invited comments from different stakeholders regarding this.

FAQsExpand AllHow does Gemsoline Softgel Capsule 15's work?Gemsoline Softgel Capsule 15's is a dietary supplement that treats low levels of calcium in the blood. It consists of Calcium, Calcitriol, and Menaquinone. Calcium is a mineral and prevents or treats calcium deficiency. 

Calcitriol, a synthetic form of Vitamin D3, treats calcium deficiency with hypoparathyroidism (the decreased activity of the parathyroid glands). Menaquinone (Vitamin K2) maintains bone density by promoting calcium transport from the bloodstream into the bone.What happens if I miss a dose?If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.Can I take Gemsoline Softgel Capsule 15's with milk?Milk is considered to be the best source of calcium. You can take Gemsoline Softgel Capsule 15's with milk.Does Gemsoline Softgel Capsule 15's cause kidney stones?Gemsoline Softgel Capsule 15's can cause kidney stones due to excess calcium deposition when used for a prolonged period. Please consult your doctor before taking Gemsoline Softgel Capsule 15's as a daily supplement if you have any kidney problems or a history of kidney stones.Can I take Gemsoline Softgel Capsule 15's if I suffer from hypercalcemia (high levels of calcium in the blood)?Gemsoline Softgel Capsule 15's is used to increase low levels of calcium in the body. Hence it is not advised to use Gemsoline Softgel Capsule 15's during hypercalcemia, since it causes the overdose of calcium leading to kidney stones and other effects.Can I take Gemsoline Softgel Capsule 15's if I am undergoing dialysis?Calcitriol in Gemsoline Softgel Capsule 15's can increase inorganic phosphate levels in serum; hence it should be cautiously used in patients undergoing dialysis to maintain adequate phosphorus levels and avoid ectopic calcification (calcium deposition). It is advised to follow a low phosphate diet to control serum phosphorus levels in patients undergoing dialysis.

Manufacturing and priceGelatin capsules are being used worldwide for the past 100 years with known safety and toxicity profile. Gelatin is easily available from hydrolysis of collagen whereas manufacturing of HPMC is a synthetic process.

 Raw materials for gelatin are readily available in the market which can fulfill the requirement of industries in India whereas raw materials for non-gelatin are quite less available and hence they are four times costlier than their gelatin counterpart. Moreover, most of the vegetable capsule shell technologies are in patent period, contributing to the cost component of these capsule shells.

The observations of Cole et al., 2004, describe that there is very little difference between HPMC capsules and conventional hard gelatin shells' in vivo and in vitro kinetic characteristics which is supported by Tuleu et al., 2007. Dissolution of both types of capsule shell was similar in water, whereas acidic environment (pH 1.2) and cations (K+/PO4 buffer) hinder HPMC capsule shell opening. Despite difference, there was no significant difference observed in terms of pharmacokinetic parameters such as Cmax and area under the curve. However, individuals fasted had lower mean disintegration time in case of gelatin capsules, compared to HPMC shells.

Both hard and soft capsule shells can be prepared from gelatin. Presence of 12%–16% moisture is essential for maintaining the integrity of gelatin hard capsule shell. Plasticizers, especially nonvolatile plasticizers, are used in the manufacturing of soft shells. These plasticizers reduce interaction between protein molecules and allow retention of moisture by gelatin. Glycerol and sorbitol are used commonly, but sorbitol is associated with blooming (crystallization), when stored at low humid temperature

. Hence, glycerol is blended with sorbitol. Polyethylene glycols (PEGs) can also be used.

A: Milk, curd, cheese, paneer and other dairy products, chinese cabbage, kale, broccoli and milk products. Zinc is found in beans, nuts, certain types of seafood (such as crab and lobster), whole grains, etc.

Will Gemsoline-D3 60K Soft Gelatin Capsule 4's reduce my fertility?There's no strong evidence to suggest that taking Gemsoline-D3 60K Soft Gelatin Capsule 4's will reduce fertility in either men or women. However, it is advisable to consult a doctor before taking it if you're likely to get pregnant or pregnant.Is there any lifestyle help for reducing bad cholesterol in our blood?Increase your daily diet with fiber, fruits, vegetables, whole grains, and fish, and cut saturated fat as well. Stop smoking and drinking and try to work out every day as well.

Can I stop taking Gemsoline-D3 60K Soft Gelatin Capsule 4's without the doctor's advice?No, you should not stop taking Gemsoline-D3 60K Soft Gelatin Capsule 4's without consulting your doctor. Please take advice from the doctor before quitting.In which condition should I not take Gemsoline-D3 60K Soft Gelatin Capsule 4's?People affected with hypothyroidism (underactive thyroid), muscle weakness, joint pain, kidney disease, diabetes, liver disease, uncontrolled epilepsy, high or low potassium level, or severely low blood pressure.Can intake of Gemsoline-D3 60K Soft Gelatin Capsule 4's harm my baby in the pregnancy stage?There is no firm clinical evidence stating that an intake of Gemsoline-D3 60K Soft Gelatin Capsule 4's causes harm to the baby. However, Gemsoline-D3 60K Soft Gelatin Capsule 4's passes into the breast milk and may harm the baby.

 It is advisable to consult a doctor if you are a nursing mother and taking Gemsoline-D3 60K Soft Gelatin Capsule 4's.Can Yoghurt lower cholesterol?Yogurt is a probiotic which can help in lowering the raised cholesterol level if taken with Gemsoline-D3 60K Soft Gelatin Capsule 4's. Yogurt eaters have a better metabolic profile than those who didn't eat yogurt.Are eggs bad for cholesterol?Egg yolks (yellow part of the egg) are high in cholesterol and rich in saturated fatty acids with a greater effect on our blood cholesterol levels. However, you can take a minimum of 3 whole eggs per day as eggs are considered a good source of HDL (good cholesterol). 

If you have high cholesterol, please consult a doctor regarding intake of the yolk part of the egg.

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MONOCEF O TABLET USE

MONOCEF O TABLET

Post a Comment Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site. Notify me when reply is posted I agree to the terms and conditions Post Comment Your comments are automatically posted once they are submitted. All comments are however constantly reviewed for spam and irrelevant material (such as product or personal advertisements, email addresses, telephone numbers and website address). Such insertions do not conform to our policy and 'Terms of Use' and are either deleted or edited and republished.Please keep your comments brief and relevant.This section may also have questions seeking help. If you have the information you are welcome to respond, but please ensure that the information so provided is genuine and not misleading.



A:Components of Monocef-O 200 tablet are known to pass into the breastmilk but in small amounts. However, it can be used while breastfeeding. In case of diarrhoea or mucosal fungal infection in the breastfed baby, consult your doctor for further information.



You may experience side effects on your liver after taking Monocef O. If this happens, then discontinue its use. Consult your medical practitioner, do as he/she suggests.



Monocef-O 100 Oral Suspension 30 ml belongs to the group of antibiotic medicines called 'cephalosporins' used to treat a wide range of bacterial infections of the ear, nose, throat, lower respiratory tract, urinary tract, skin, and soft tissue. Monocef-O 100 Oral Suspension 30 ml is a broad-spectrum antibiotic that is effective against gram-positive and gram-negative bacteria, aerobic and some anaerobic bacteria. Monocef-O 100 Oral Suspension 30 ml works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria and helping in treating and preventing the spread of infections. Monocef-O 100 Oral Suspension 30 ml has been shown to reduce the development of antibiotic-resistant bacteria.

Do not take Monocef-O 100 Oral Suspension 30 ml on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Talk to your doctor before taking Monocef-O 100 Oral Suspension 30 ml if you have had inflammation in bowel, kidney or liver problems. Do not take antacids and anti-ulcer medicines along with Monocef-O 100 Oral Suspension 30 ml; maintain a gap of 2-3 hours between both. Consult your doctor before taking Monocef-O 100 Oral Suspension 30 ml if you are pregnant or breastfeeding. Monocef-O 100 Oral Suspension 30 ml may cause dizziness, so be cautious while driving. Avoid alcohol consumption to prevent unpleasant side effects. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side effects.

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Monocef-O 100 Oral Suspension 30 ml should be preferably taken with food to avoid stomach upset. It is recommended to complete the course of medicine even if you feel better as it is an antibiotic, and leaving it in between may lead to even severe infection that will, in fact, stop responding to the antibiotic as well (antibiotic resistance). In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea (watery or loose stool), abdominal pain, loss of appetite, bloating, skin rash and itching. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Is the use of Monocef O 200 Tablet safe for pregnant women? Pregnant women can consume .

 Though Monocef O has mild side effects when taken during pregnany Mild Is the use of Monocef O 200 Tablet safe during breastfeeding? Monocef O may lead to some side effects in breastfeeding women. If you witness any unusal symptoms after taking Monocef O, discontinue its use and call your doctor right away. Follow your doctor's advice regarding the use of Monocef O. Moderate What is the effect of Monocef O 200 Tablet on the Kidneys? Monocef O may cause harmful effects on kidney. if you feel its having any such effect, then stop taking this drug, and restart only on your doctor's advice. Moderate What is the effect of Monocef O 200 Tablet on the Liver?

 You may experience side effects on your liver after taking Monocef O. If this happens, then discontinue its use. Consult your medical practitioner, do as he/she suggests. Moderate What is the effect of Monocef O 200 Tablet on the Heart? Monocef O may have mild side effects on the heart. Most people will never see any effect on the heart. Mild

Question about 3 years ago Can I take Monocef O with doxycycline? Dr. Abhijit MBBS , General Physician Monocef O and doxycycline can be taken together, as there are no reported harmful interactions between them. However, it doesn't mean that no interactions exist between them. Please take if prescribed by a doctor.

Do not take Monocef-O 100 Oral Suspension 30 ml if you are allergic to cefpodoxime or any antibiotics. Taking antibiotics of own or practising self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Before taking Monocef-O 100 Oral Suspension 30 ml, let your doctor know if you have/had inflammation in bowel, kidney or liver problems. Do not take antacids and anti-ulcer medicines along with Monocef-O 100 Oral Suspension 30 ml and maintain a gap of 2-3 hours between both to avoid any drug interaction. Consult a doctor before taking Monocef-O 100 Oral Suspension 30 ml if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Monocef-O 100 Oral Suspension 30 ml to prevent unpleasant side effects. Monocef-O 100 Oral Suspension 30 ml may cause dizziness, so be cautious while driving.

INTRODUCTIONMONOCEF O 200MG contains Cefpodoxime which belongs to the group of medicines called Antibiotics. It is used to treat infections caused by bacteria such as otitis media (inflammation of middle ear leading to pain and fever), tonsilitis (sore throat, difficulty swallowing and tender lymph nodes), chronic bronchitis (inflammation of the airways present in the lungs leading to cough with mucus), community acquired pneumonia (inflammation of lungs leading to congestion), gonorrhoea (sexually transmitted infection in rectum, cervix or vagina), skin structure infections (rashes, swelling, 

redness, pain, pus, and itching), maxillary sinusitis (inflammation around the nasal cavity leading to headache and runny nose) and cystitis (strong, persistent urge to urinate with burning sensation and blood in the urine). MONOCEF O 200MG should be avoided if you are allergic to cefpodoxime or to the cephalosporin group of antibiotics (such as cefuroxime, cefixime) or if you had experienced immediate or severe allergic reaction (anaphylaxis) to penicillin or other beta-lactam antibiotics (such as ampicillin). Before taking MONOCEF O 200MG, inform your doctor if you have or ever had colitis, liver problems and impaired kidney function. Your doctor may monitor your blood count and liver enzymes through blood tests while taking MONOCEF O 200MG. MONOCEF O 200MG should be used with caution in pregnant women unless clearly advised by the doctor and it is not recommended for use in breastfeeding women. MONOCEF O 200MG is not recommended for use in infants (less than 2 months of age) and it should be used with caution in elderly patients. The most common side effects of taking MONOCEF O 200MG are diarrhoea, nausea, itching and irritation in the vagina and vulva, abdominal pain and headache Consult your doctor if any of the symptom worsens.

Avoid taking Monocef O with azithromycin, because it can cause heart-related problems.

 However, if you are experiencing any discomfort after consuming these two medicines at the same time then do not hesitate to inform your doctor.

No, you should not take Monocef-O 200 tablet without consulting the doctor.This medicine is a higher antibiotic meant for severe infections and your doctor will prescribe you the same only if it is essential.This medication is not for viral infections and generally, flu occurs due to viruses.

Storage and disposal of Monocef O 200 MGStore Monocef-O 200 tablet in a cool and dry place, protect it from direct sunlight, moisture and heat. Keep it away from children and pets.Do not use expired or damaged medicines. Discard unused medicine properly. Do not flush it in the toilet or throw it into the drain.

With an aim to eradicate fake and ineffective medicines, and supply high-quality medicines in India, MedPlus was launched in 2006 in Hyderabad. According to WHO research, every 1 or 2 in 10 medicines are proven to be adulterated in low/medium income countries like India and MedPlus aspires to bring about a change in this statistic. To encourage and elevate transparency in the functioning of the pharmaceutical industry, MedPlus has been successfully contributing in providing genuine and unadulterated medicines since its inception. Currently operating in 300+ cities, with 1500+ offline stores in India, MedPlus is the second largest pharmacy chain in India today. Welcome to a seamless and impeccable shopping experience!

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ITRACONAZOLE CAPSULE USE

ITRACONAZOLE CAPSULES USE

Solution formulation. Most studies examining the efficacy of itraconazole solution have been in patients with impaired immunity. 13,55,56,57,58,59,60,61 Two large comparative studies with fluconazole (Table III) were in HIV-positive patients with oral (n = 244),57 or oropharyngeal (n = 190)58 candidosis: 14 days of itraconazole solution was at least as effective as fluconazole in effecting a clinical response (≥87%). In a further study of 126 immunocompromised patients with oesophageal candidosis, itraconazole solution and fluconazole led to a clinical response in 94% and 91% of cases, respectively.60 A comparative study examining the prophylactic use of itraconazole solution and fluconazole in 445 patients who were expected to be neutropenic following chemotherapy demonstrated that both agents prevent fungal infections in most cases (>97%).59

Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration. As a consequence of non-linear pharmacokinetics, itraconazole accumulates in plasma during multiple dosing. Steady-state concentrations are generally reached within about 15 days, with Cmax values of 0.5 μg/mL, 1.1 μg/mL and 2.0 μg/mL after oral administration of 100 mg once daily, 200 mg once daily and 200 mg b.i.d., respectively. The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing. Once treatment is stopped, itraconazole plasma concentrations decrease to an almost undetectable concentration within 7 to 14 days, depending on the dose and duration of treatment. Itraconazole mean total plasma clearance following intravenous administration is 278 mL/min. Itraconazole clearance decreases at higher doses due to saturable hepatic metabolism.



Its use in dogs, small mammals, and some exotics to treat fungal infections is 'off label' or 'extra label'. Use of the human version of this drug is 'off label' or 'extra label' in both cats and dogs. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully as their directions may be significantly different from those on the label.



It has been experimentally demonstrated that as the pellets in each unit increase, the dissolution rate also increases. Pellet number within a capsule would directly depend on the pellet size and determines the surface area presented for absorption in the gastrointestinal (GI) tract. Thus, smaller pellets would result in larger pellet numbers as seen in our analysis (r = −0.848, P < 0.0001). On the same lines, we observed a significant difference (with P < 0.0001) in average pellet size of brands with >500 pellets versus those with <300 pellets, with significantly smaller pellets in the former . A similar statistically significant difference was also found in the average sizes of pellets among the brands with 300–500 pellets and those with <300 pellets. Brands 7 and 16 had unusually big pellets (1571 and 1845 μm) leading to very low pellet counts of 121 and 135, respectively.



Itraconazole was found to cause a dose-related increase in maternal toxicity, embryotoxicity, and teratogenicity in rats at dosage levels of approximately 40-160 mg/kg/day (5-20 times the MRHD), and in mice at dosage levels of approximately 80 mg/kg/day (10 times the MRHD). Itraconazole has been shown to cross the placenta in a rat model. In rats, the teratogenicity consisted of major skeletal defects; in mice, it consisted of encephaloceles and/or macroglossia.

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Alcohol may also increase the risk of serious liver problems.

ITRACONAZOLE belongs to a class of drugs called antifungals used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. Fungal infection is a disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).

As per the cost, nine brands had a per-capsule price of more than Rs. 20 rupees, whereas 11 were between Rs. 10 and 20 and only 2 below Rs. 10. Considering a dosage of 100 mg once a day, the cost of a standard 15 day treatment would fall between Rs. 180 and Rs 1215. And the treatment dosages and durations being given by many are much higher than the approved doses. Furthermore, use of 200 mg and higher dose capsule formulations (amply available in the Indian market) in this regard may produce suboptimal response. This is because keeping the same pellet size and technology, a 200-mg drug load formulation would require a much larger capsule size. The change in pellet size by altering the drug–polymer ratio or removing PEG 20000 layer leads to instable formulations with a negative impact on bioavailability.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Special patient populations. The volume of distribution and clearance of fluconazole are greater in children than in adults;19 a relatively high mg/kg dose of fluconazole is therefore necessary in young patients. For those aged greater than 4 weeks, once daily dosing is appropriate. Neonates (aged ≤4 weeks) excrete fluconazole slowly, and less frequent dosing is therefore desirable. 19,20 The pharmacokinetics of fluconazole in the elderly are similar to those in non-elderly adults.15 Immune status has no effect on the pharmacokinetics of fluconazole in either adultsor children. 7,21,22

Itraconazole showed no evidence of carcinogenicity potential in mice treated orally for 23 months at dosage levels up to 80 mg/kg/day (approximately 10 times the maximum recommended human dose ). Male rats treated with 25 mg/kg/day (3.1 times the MRHD) had a slightly increased incidence of soft tissue sarcoma. These sarcomas may have been a consequence of hypercholesterolemia, which is a response of rats, but not dogs or humans, to chronic itraconazole administration. Female rats treated with 50 mg/kg/day (6.25 times the MRHD) had an increased incidence of squamous cell carcinoma of the lung (2/50) as compared to the untreated group. Although the occurrence of squamous cell carcinoma in the lung is extremely uncommon in untreated rats, the increase in this study was not statistically significant.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how the medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Dosage Guidelines & TipsHow to take Itraconazole (Sporanox)?Use Itraconazole (Sporanox) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.Do not share this medicine with another person, even if they have the same symptoms you have.The itraconazole capsule should be taken with food.Swallow the capsule whole and do not crush, chew, break, or open it.Take itraconazole oral solution (liquid) on an empty stomach, at least 1 hour before or 2 hours after a meal. Swish the liquid in your mouth for several seconds before swallowing it.Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).The Sporanox PulsePak has a special dosing schedule that includes not taking the medicine for several days in a row.

 Follow all dosing instructions carefully.Itraconazole capsules should not be used in place of itraconazole oral solution (liquid) if that is what your doctor has prescribed. Avoid medication errors by using only the form and strength your doctor prescribes.If you also take a stomach acid reducer (Tagamet, Pepcid, Axid, Zantac, and others), take itraconazole with an acidic drink such as non-diet cola.Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Itraconazole will not treat a viral infection such as the flu or a common cold.You may need frequent medical tests.Store at room temperature away from moisture, heat, and light.What should I do if I missed a dose of Itraconazole (Sporanox)?Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

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