ACECLOFENAC TABLET USE
You have been prescribed Aceclofenac to relieve pain and inflammation.
Take it with food or milk to prevent upset stomach. Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems. It may cause dizziness, drowsiness or visual disturbances.
Use caution while driving or doing anything that requires concentration. Avoid consuming alcohol while taking Aceclofenac as it can cause excessive drowsiness and increase your risk of stomach problems.
Inform your doctor if you have a history of heart disease or stroke. Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.
Appropriate monitoring and advice are required for patients with a history of hypertension and/or mild to moderate congestive heart failure as fluid retention and oedema have been reported in association with NSAID therapy.
Patients with congestive heart failure ( NYHA-I) and patients with significant risk factors for cardiovascular events (e.g. hypertension, hyperlipidaemia, diabetes mellitus, smoking) should only be treated with aceclofenac after careful consideration. As the cardiovascular risks of aceclofenac may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic relief and response to therapy should be re- evaluated periodically.
Hypersensitivity to Aceclofenac or to any of the excipients listed in section 6.1 Active, or history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding). NSAIDS are contraindicated in patients who have previously shown hypersensitivity reactions (eg. Asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs. Hepatic failure and renal failure (see section 4.4). Patients with established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease. History of gastrointestinal bleeding or perforation, related to previous NSAIDS therapy. Active bleedings or bleeding disorders. Aceclofenac should not be prescribed during pregnancy, especially during the last trimester of pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used (see section 4.6).
The in vitro API release data presented a substantial improvement in dissolution rate of batch ACN-1 in comparison to marketed tablets and unprocessed aceclofenac-based tablet formulation. The graph showed that in the first 30 min, more than 85% of ACN-1 were dissolved compared to 75.89% for ACN-2, 51.06% for unprocessed micronized drug formulation (i.e. ACM-3), 59.56% for the M. Tablets and 29.41% for raw drug. Boosted in vitro release rate of ACN-1 was observed while comparing to ACN-2, unprocessed drug containing formulation i.e. ACM-3, M. Tablets and raw drug, all these results are illustrated in Figure 7. The solubility of drug compound will be enhanced when the particle size of the drug is reduced to nanosized range as described by Xia et al.33 The release data showed the P<0.001 compared with raw drug. Figure 7 In vitro dissolution of formulations and M. Tablets. Values represent mean±SD, n=3. ***P<0.001 compared with raw drug.
NSAIDs are contraindicated in patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs.
The majority of side effects observed have been reversible and of a minor nature and include gastrointestinal disorders (dyspepsia, abdominal pain, nausea), rash, ruber, urticaria, symptoms of enuresis, headache, dizziness, and drowsiness. To report suspected adverse reactions, call 1-800-FDA-1088.
The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation (see section 4.3), and in the elderly. These patients should commence treatment on the lowest dose available. Combination therapy with protective agents (e.g. misoprostol or proton pump inhibitors) should be considered for these patients, and also for patients requiring concomitant low dose aspirin, or other drugs likely to increase gastrointestinal risk (see below and section 4.5).
Interactions with other medicinesSome medicines can affect the way aceclofenac+thiocolchicoside works or this medicine itself can reduce the effectiveness of other medicines taken at the same time. Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.Increased risk of stomach bleeding, if you take other pain killers, steroids, antidepressants along with this combination.Concomitant use of cyclosporine and tacrolimus (used in organ transplants) can lead to serious kidney damage.There is an increased risk of bleeding if aceclofenac+thiocolchicoside is taken along with other medicines like warfarin.You may experience fluctuations in blood sugar if you are taking anti-diabetic medicines like glimepiride or metformin.Do not take aceclofenac+thiocolchicoside if you have taken mifepristone lately (within 2 weeks).This combination can worsen the heart failure problem if taken with medicines for heart failure like digoxin.You may experience fits if you are taking antibiotics like ciprofloxacin, norfloxacin and ofloxacin.
a) Symptoms Symptoms include headache, nausea, vomiting, epigastric pain, gastrointestinal irritation, gastrointestinal bleeding, rarely diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, occasionally convulsions. In cases of significant poisoning acute renal failure and liver damage are possible. b) Therapeutic measure : Patients should be treated symptomatically as required. Within one hour of ingestion of a potentially toxic amount, activated charcoal should be considered. Alternatively, in adults, gastric lavage should be considered within one hour of ingestion of a potentially life-threatening overdose. Specific therapies such as, dialysis or haemoperfusion are probable of no help in eliminating NSAIDs due to their high rate of protein binding and extensive metabolism. Good urine output should be ensured. Renal and liver function should be closely monitored. Patients should be observed for at least four hours after ingestion of potentially toxic amounts. In case of frequent or prolonged convulsions, patients should be treated with intravenous diazepam. Other measures may be indicated by the patient's clinical condition. Management of acute poisoning with oral aceclofenac essentially consists of supportive and symptomatic measuresfor complications such as hypotension, renal failure, convulsions, gastro-intestinal irritation, and respiratory depression.
Hifenac (aceclofenac) 100mg Tablet is a Tablet manufactured by Intas Pharmaceuticals Ltd. It is commonly used for the diagnosis or treatment of osteoarthritis, rheumatoid arthritis, Ankylosing spondylitis, headache, mentrual pain.
It has some side effects such as Peptic ulcer, Abdominal pain, Nausea, Liver injury. The salts Aceclofenac are involved in the preparation of Hifenac (aceclofenac) 100mg Tablet.
This article has been medically reviewed by Dr Nikita Toshi. Isn’t it a common practice to have something special for dinner or lunch when you have a reason to celebrate? Similarly, it is not unusual for many people to skip a meal or overeat when feeling low or angry. When we are feeling down or happy, Read More
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To investigate the mechanism of drug release from the formulated tablets, the drug release data were fitted into zero-order, first-order, Higuchi and Korsmeyer’s equation. The Korsmeyer’s equation, Equation (A), describes the drug release behaviour from the polymers.
There are no human data available on the consequences of CLANZA CR overdosage. If overdosage is observed, therapeutic measures should be taken according to symptoms; supportive and symptomatictreatment should be given for complications such as hypotension, gastro-intestinal irritation, respiratory depression, and convulsions.
Expert advice for AceclofenacYou have been prescribed Aceclofenac to relieve pain and inflammation. Take it with food or milk to prevent upset stomach. Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems. It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration. Avoid consuming alcohol while taking Aceclofenac as it can cause excessive drowsiness and increase your risk of stomach problems. Inform your doctor if you have a history of heart disease or stroke. Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.Frequently asked questions for AceclofenacAceclofenacQ. Is Aceclofenac a good painkiller?Aceclofenac is effective in relieving pain and inflammation. It is used to provide relief from various sorts of pain such as sprains, strains and other injuries. It is also helpful in various types of arthritis, gout, pain and inflammation following surgery.Q. Is Aceclofenac safe?Aceclofenac is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.Q. Does Aceclofenac get you high?No, Aceclofenac does not get you high. It does not have an abuse potential (drug-seeking behavior) and does not cause physical or psychological dependence. However, if you do not feel well, consult your doctor.Q. Can Aceclofenac hurt your kidneys?Long-term use and high doses of Aceclofenac may cause renal problems, such as protein or blood in urine and pain during urination. Patients who had or have heart failure, impaired kidney function and hypertension are at risk of kidney problems. The risk of developing kidney problems is also high in patients who are on medicines which cause excess urination (diuretics), or medicines which have significant impact on kidney function. Along with that, Aceclofenac can affect kidneys of patients who are above 65 years of age or who remain dehydrated. Therefore, kidney function monitoring is recommended for such patients.Q. What if I forget to take a dose of Aceclofenac?If you forget a dose of Aceclofenac, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.Q. Does Aceclofenac make you drowsy?Aceclofenac can cause drowsiness and also dizziness, fatigue (tiredness) and visual disturbances. However, it is not very common and may not affect everyone. If you experience these symptoms avoid driving or operating heavy machinery.Q. What is the most important information I need to know about Aceclofenac?It is important to know that Aceclofenac may increase your chance of having a heart attack or stroke. The risk is more if you take higher doses and have been using the medicine for a longer time. Also, the use of Aceclofenac may cause ulcers, bleeding, or holes in your stomach and intestine. These problems may happen without warning symptoms at any time during treatment and may even cause death. Therefore, if you encounter any such problems, consult your doctor immediately.Q. Can Aceclofenac be taken during pregnancy?You should not take Aceclofenac during the last 3 months of pregnancy as it may cause harmful effects on your baby. Use of Aceclofenac can also lead to reduced labor (premature delivery). Hence, it is advised to avoid using Aceclofenac during the first 6 months of pregnancy also. In some cases, Aceclofenac may be prescribed in pregnant women only if the benefits outweigh the risks involved with its use in pregnant women. If not sure, consult your doctor regarding its use.Q. Is Aceclofenac effective?Aceclofenac is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Aceclofenac too early, the symptoms may return or worsen.